|
KMID : 0380020040190060433
|
|
Korean Journal of Biotechnology and Bioengineering
2004 Volume.19 No. 6 p.433 ~ p.436
|
|
|
Effects of Red Ginseng Total Saponin on the Polycystic Ovaries in Rats
|
|
Lim Sung-Chul
Ryu Ae-Ran
Bae Jin-Gyu
Kang Sung-Soo
Kim Jong-Choon
Kim Seong-Ho
Kim Jung-Wook
Choi Bum-Chae
Bae Chun-Sik
|
|
|
Abstract
|
|
|
|
Polycystic ovarian syndrome (PCOS) is a very common endocrine disorder in women of reproductive age. There are some evidences that nerve growth factor (NGF) is involved in the pathogenesis of PCOS. In this study, we investigated the effect of Korean red ginseng total saponin (GTS) on the ovarian morphology and NGF expressions in the ovaries, pituitary and hippocampus. The oil control animals were injected with 0.2 ml oil/rat. Animals in estradiol valerate (EV) control group were injected i.m. with 4 mg EV in 0.2 ml oil/rat. The GTS was administered (100 mg/kg) i.p. every other day for 60 days, beginning 1 day after the EV injection. PCO was induced by a single injection of EV (4 mg, i.m.). At day 60, the expressions of NGF were examined by immunohistochemistry. The main findings were as follows; PCO was fully developed with a single i.m. injection of EV, and PCO showed the increased expression of NGF, and GTS administration decreased NGF expressions in the ovaries without affecting pituitary and hippocampus significantly. The present results demonstrate that GTS attenuates PCOS by the stimulation of NGF expression.
|
|
|
KEYWORD
|
|
|
PCO, nerve growth factor, estradiol valerate, saponin, rat
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|